Creatine Monohydrate: The Gold-Standard Ingredient in Evidence-Based Nutrition
For more than three decades—and 2,000+ peer-reviewed studies—creatine monohydrate has stood out as one of the most rigorously researched dietary supplements ever released. Its safety profile is repeatedly affirmed by leading sports-science bodies, while benefits now extend far beyond the weight room to cognition, healthy aging, metabolic health, and more.
New data emerge almost every month, adding depth to what we know about optimal dosing, timing, and the diverse populations that can benefit. Project Creatine is committed to keeping this page current, so you’ll always find the latest findings, infographics, and practical guides the moment they’re published. Education and research will always be our first priority—every formula we launch is backed by the same peer-reviewed evidence highlighted here.
Below are just a few research themes we track and be sure to bookmark this page and check back often. The science of creatine isn’t standing still, and neither are we.
Neurological & Cognitive Health
-
Effects of Creatine Supplementation on Brain Function and Health
Brain Health -
Creatine Supplementation in Depression: A Review of Mechanisms, Efficacy, Clinical Outcomes, and Future Directions
Depression Support -
The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis
Cognitive Decline -
Potential for use of creatine supplementation following mild traumatic brain injury
Concussion Support -
Effect of creatine supplementation and sleep deprivation, with mild exercise, on cognitive and psychomotor performance, mood state, and plasma concentrations of catecholamines and cortisol
Sleep Deprivation -
Six-Week Supplementation with Creatine in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Magnetic Resonance Spectroscopy Feasibility Study at 3 Tesla
Chronic Fatigue
Musculoskeletal Health
-
Creatine Supplementation for Muscle Growth: A Scoping Review of Randomized Clinical Trials from 2012 to 2021
Muscle Strength -
The power of creatine plus resistance training for healthy aging: enhancing physical vitality and cognitive function
Sarcopenia Prevention -
Creatine monohydrate in muscular dystrophies: A double-blind, placebo-controlled clinical study
Muscular Dystrophy -
Creatine Supplementation (3 g/d) and Bone Health in Older Women: A 2-Year, Randomized, Placebo-Controlled Trial
Bone Density -
The effect of creatine supplementation on strength recovery after anterior cruciate ligament (ACL) reconstruction: a randomized, placebo-controlled, double-blind trial
Post-Surgery Recovery
Physical Performance
Metabolic & Hormonal Health
-
Role of Creatine Supplementation in Conditions Involving Mitochondrial Dysfunction: A Narrative Review
Mitochondrial Disorders -
Creatine supplementation in chronic heart failure increases skeletal muscle creatine phosphate and muscle performance
Heart Failure -
The Paradoxical Effect of Creatine Monohydrate on Muscle Damage Markers: A Systematic Review and Meta-Analysis
Inflammation Control -
Creatine Supplementation (3 g/d) and Bone Health in Older Women: A 2-Year, Randomized, Placebo-Controlled Trial
Menopause Support
Women's Health
-
Creatine Supplementation in Women’s Health: A Lifespan Perspective
Women’s Health -
A 2-yr Randomized Controlled Trial on Creatine Supplementation during Exercise for Postmenopausal Bone Health
Postmenopausal Bone Density -
The Effects of Creatine Monohydrate Loading on Exercise Recovery in Active Women throughout the Menstrual Cycle
Exercise Training -
Does Creatine Supplementation Enhance Performance in Active Females? A Systematic Review
Exercise Training -
Creatine Supplementation Associated or Not with Strength Training upon Emotional and Cognitive Measures in Older Women: A Randomized Double-Blind Study
Brain Health